Information om friska katter av tre raser: burma, birma och maine coon. Data om katterna (ex ålder och vikt) samt hormonkoncentrationer i blodserum.

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dc.contributor.authorBodil Ström Holst
dc.contributor.authorMalin Öhlund
dc.contributor.authorAli Moazzami
dc.contributor.authorElisabeth Mullner
dc.contributor.authorFredrick Anderson
dc.date.accessioned2021-12-07T08:42:59Z
dc.date.available2021-12-07T08:42:59Z
dc.date.issued2021-04-06T05:48:16.030723Z
dc.descriptionStudien beskriver metabolomet hos tre kattraser med olika hög risk att utveckla diabetes mellitus. Se vidare engelsk sammanfattning. Studien godkändes av Uppsala Djurförsöksetiska nämnd, diarienummer C 299/12 och C 12/15, samt av Jordbruksverket, diarienummer 31-11654/12.sv_SE
dc.descriptionBlodprov har tagits från friska katter av tre raser; burma, birma och maine coon. Katterna har undersökts kliniskt och uppgifter om dem har noterats. Serum har analyserats avseende hormoner med immunologiska metoder, lipoproteiner har analyserats med HPLC (high performance liquid chromatography) och metabolomics studerades med NMR-spektroskopi (nuclear magnetic resonance spectroscopy).sv_SE
dc.descriptionFeline diabetes mellitus shares many features with type 2 diabetes in people, regarding clinical presentation, physiology, and pathology. A breed predisposition for type 2 diabetes has been identified, with the Burmese breed at a fivefold increased risk of developing the condition compared to other purebred cats. We aimed to characterize the serum metabolome in cats (n = 63) using nuclear magnetic resonance metabolomics, and to compare the metabolite pattern of Burmese cats with that of two cat breeds of medium or low risk of diabetes, the Maine coon (MCO) and Birman cat, respectively. Serum concentrations of adiponectin, insulin and insulin-like growth factor-1 were also measured (n = 94). Burmese cats had higher insulin and lower adiponectin concentrations than MCO cats. Twenty one metabolites were discriminative between breeds using a multivariate statistical approach and 15 remained significant after adjustment for body weight and body condition score. Burmese cats had higher plasma levels of 2-hydroxybutyrate relative to MCO and Birman cats and increased concentrations of 2-oxoisocaproic acid, and tyrosine, and lower concentrations of dimethylglycine relative to MCO cats. The metabolic profile of MCO cats was characterized by high concentrations of arginine, asparagine, methionine, succinic acid and low levels of acetylcarnitine while Birman cats had the highest creatinine and the lowest taurine plasma levels, compared with MCO and Burmese. The pattern of metabolites in Burmese cats is similar to that in people with insulin resistance. In conclusion, the metabolic profile differed between healthy cats of three breeds. Detection of an abnormal metabolome might identify cats at risk of developing diabetes. The study was approved by the ethics committee on animal experiments in Uppsala, reference number C 299/12 and C 12/15, and by the Swedish Board of Agriculture, reference number 31-11654/12.en_EN
dc.descriptionResults from analysis of blood samples from healthy cats of three breeds: Burmese, Birman and Maine coon, are included. A clinical examination was performed on the cats and information noted. Hormones were analysed in serum using immunological methods. Lipoproteins were analysed using HPLC (high performance liquid chromatography) and metabolomics using NMR (nuclear magnetic resonance) spectroscopy.en_EN
dc.description.sponsorshipSällskapsdjurens forskningsfondsv_SE
dc.description.sponsorshipResearch Fund for Companion Animals at SLUen_EN
dc.description.version1
dc.identifier.govdocSLU.kv.2016.4.1-160
dc.identifier.urihttps://doi.org/10.5878/smjp-vh85
dc.identifier.urihttps://archive-harvest.slu.se:8443/jspui/handle/20.500.12703/3929
dc.language.isosv_SEsv_SE
dc.language.isoen_ENen_EN
dc.publisherSveriges lantbruksuniversitet, institutionen för kliniska vetenskapersv_SE
dc.publisherSwedish University of Agricultural Sciences, Department of Clinical Sciencesen_EN
dc.subjectDiabetessv_SE
dc.subjectMänniskors hälsa och säkerhetsv_SE
dc.subjectHormonsjukdomarsv_SE
dc.subjectGlukosomsättningsstörningarsv_SE
dc.subjectÄmnesomsättningssjukdomarsv_SE
dc.subjectNäringsrubbningar och ämnesomsättningssjukdomarsv_SE
dc.subjectDiabetes Mellitusen_EN
dc.subjectHuman health and safetyen_EN
dc.subjectEndocrine System Diseasesen_EN
dc.subjectGlucose Metabolism Disordersen_EN
dc.subjectMetabolic Diseasesen_EN
dc.subjectNutritional and Metabolic Diseasesen_EN
dc.titleInformation om friska katter av tre raser: burma, birma och maine coon. Data om katterna (ex ålder och vikt) samt hormonkoncentrationer i blodserum.sv_SE
dc.titleInformation on healthy cats of three breeds; Burmese, Birman and Maine coon. Data on the cats (e.g. age and weight) and on serum blood concentrations.en_EN
dc.typedatasetsv_SE
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Skillnad i metabola profiler mellan katter av raserna burma, maine coon och birma - tre raser med olika hög risk att utveckla diabetes mellitus